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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SMC4
All Species:
15.76
Human Site:
S574
Identified Species:
21.67
UniProt:
Q9NTJ3
Number Species:
16
Phosphosite Substitution
Charge Score:
-0.06
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9NTJ3
NP_001002800.1
1288
147182
S574
Q
E
E
T
N
F
K
S
L
V
H
D
L
F
Q
Chimpanzee
Pan troglodytes
XP_001157958
1288
147223
S574
Q
E
E
T
N
F
K
S
L
V
H
D
L
F
Q
Rhesus Macaque
Macaca mulatta
XP_001099428
1287
147121
S573
Q
E
E
I
N
F
K
S
L
V
H
D
L
F
Q
Dog
Lupus familis
XP_535848
1288
147094
G574
Q
E
E
I
K
L
K
G
L
V
R
D
L
F
Q
Cat
Felis silvestris
Mouse
Mus musculus
Q8CG47
1286
146876
S572
Q
E
E
I
N
L
K
S
L
V
H
D
L
F
Q
Rat
Rattus norvegicus
Q9Z1M9
1233
143186
K529
L
C
Q
P
T
Q
K
K
Y
Q
I
A
V
T
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001510551
1069
122201
V418
G
A
L
D
H
I
V
V
N
T
I
D
T
A
Q
Chicken
Gallus gallus
NP_989849
1274
145838
D545
K
E
E
L
N
A
Q
D
L
V
R
N
L
R
Q
Frog
Xenopus laevis
P50532
1290
146971
N568
S
E
E
G
N
I
K
N
Q
V
R
E
L
R
Q
Zebra Danio
Brachydanio rerio
NP_775360
1289
145687
A573
E
Q
D
K
Q
T
R
A
Q
V
G
D
M
R
Q
Tiger Blowfish
Takifugu rubipres
NP_001027927
1326
150958
E570
K
L
D
N
E
T
Q
E
V
V
R
E
M
R
Q
Fruit Fly
Dros. melanogaster
Q9VJE5
1690
189046
S829
S
K
S
A
E
S
E
S
A
L
K
V
V
Q
V
Honey Bee
Apis mellifera
XP_396862
1282
148175
S510
T
K
E
I
E
I
T
S
E
L
K
K
M
K
I
Nematode Worm
Caenorhab. elegans
Q20060
1549
176553
Q580
N
T
A
R
Q
K
N
Q
D
L
A
K
T
R
D
Sea Urchin
Strong. purpuratus
XP_797583
1289
146235
K573
G
S
M
K
L
K
H
K
F
L
K
D
L
T
V
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9FJL0
1241
141112
P516
K
E
Q
E
T
L
V
P
Q
E
Q
A
A
R
E
Baker's Yeast
Sacchar. cerevisiae
Q12267
1418
162171
K647
L
K
L
K
E
M
Q
K
V
L
N
A
H
R
Q
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.5
98.3
94
N.A.
89.5
24
N.A.
67.8
75.3
76.9
67.9
66.7
20.1
45.9
29.9
48.1
Protein Similarity:
100
99.6
98.9
96.5
N.A.
94.8
47.5
N.A.
75
86.3
87.5
83.5
81.2
40.2
63.9
47.5
65.4
P-Site Identity:
100
100
93.3
66.6
N.A.
86.6
6.6
N.A.
13.3
46.6
46.6
20
13.3
6.6
13.3
0
13.3
P-Site Similarity:
100
100
93.3
66.6
N.A.
86.6
26.6
N.A.
20
66.6
60
60
53.3
33.3
33.3
6.6
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
41.3
35.6
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
58.7
55.4
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
6.6
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
26.6
40
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
6
6
6
0
6
0
6
6
0
6
18
6
6
0
% A
% Cys:
0
6
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
12
6
0
0
0
6
6
0
0
48
0
0
6
% D
% Glu:
6
48
48
6
24
0
6
6
6
6
0
12
0
0
6
% E
% Phe:
0
0
0
0
0
18
0
0
6
0
0
0
0
30
0
% F
% Gly:
12
0
0
6
0
0
0
6
0
0
6
0
0
0
0
% G
% His:
0
0
0
0
6
0
6
0
0
0
24
0
6
0
0
% H
% Ile:
0
0
0
24
0
18
0
0
0
0
12
0
0
0
6
% I
% Lys:
18
18
0
18
6
12
42
18
0
0
18
12
0
6
6
% K
% Leu:
12
6
12
6
6
18
0
0
36
30
0
0
48
0
0
% L
% Met:
0
0
6
0
0
6
0
0
0
0
0
0
18
0
0
% M
% Asn:
6
0
0
6
36
0
6
6
6
0
6
6
0
0
0
% N
% Pro:
0
0
0
6
0
0
0
6
0
0
0
0
0
0
0
% P
% Gln:
30
6
12
0
12
6
18
6
18
6
6
0
0
6
65
% Q
% Arg:
0
0
0
6
0
0
6
0
0
0
24
0
0
42
0
% R
% Ser:
12
6
6
0
0
6
0
36
0
0
0
0
0
0
0
% S
% Thr:
6
6
0
12
12
12
6
0
0
6
0
0
12
12
0
% T
% Val:
0
0
0
0
0
0
12
6
12
53
0
6
12
0
12
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
6
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _